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15,26 Female genital pain (vulvodynia) 4 Chronic pelvic pain 4,27 Chronic low back pain 4 Arthritis , including osteoarthritis, rheumatoid arthritis, and gout 15 Temporomandibular disorder 4 Sexual dysfunction 13 Cognitive disorders 13 In addition, fibromyalgia has a bi-directional relationship with cardiometabolic conditions, including coronary artery disease, hypertension, type 2 diabetes, and obesity

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In intervention studies however, B12 has not been shown to bring about any clear improvements, as demonstrated by a meta-analysis from 2015 (11)