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The biggest impact of increasing flavanols, was seen in the COSMOS study, in those in the lowest third for dietary intake specifically seeing improvement in aspects of memory that link to the hippocampus, that central area of the brain that degenerates in Alzheimers (24)

Li, H.-Y

Role of NF-B and Akt/GSK3 pathways in the regulation of the expression and activity of CBS The compounds identified in our screening also confirm the importance not only of the Akt/GSK3 pathway but also of NF-B, which is often activated by Akt/GSK3 (Ozes et al., 1999), in the regulation of CBS activity and expression