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The liver is a key target of THs, with THs playing significant roles in liver disease pathogenesis such as alcoholic liver disease and non-alcoholic steatohepatitis [21, 22]

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On the immune front, gut microbiota can increase systemic inflammation by releasing lipopolysaccharides (LPS) and proinflammatory cytokines, and they also produce amyloids, which may stimulate neural amyloid production via immune priming