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Targeted disruption of the aromatase P450 gene (Cyp19) in mice and their ovarian and uterine responses to 17beta-oestradiol

[DOI] [PMC free article] [PubMed] [Google Scholar] 151.Atkinson SH, Uyoga SM, Armitage AE, et al

Soymorphin-Soymorphin-5 (YPFVV), a -opioid agonist peptide derived from the soybean -glycin -subunit, inhibits hyperglycemia in KKAy mice without increasing plasma insulin levels while decreasing plasma and hepatic triglyceride (TG) levels and liver weight, and promotes plasma adiponectin concentration and adiponectin receptor subtype AdipoR2 mRNA expression in the liver, PPAR in the liver after oral administration of soymorphin-5 The mRNA expression of and its target genes was also increased, effectively improving glucose and lipid metabolism in KKAy mice, a type 2 diabetes model animal (75)