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in: PubMed | Google Scholar | 1 Department of Thoracic Surgery and 2 Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, China

A methionine-restricted diet can suppress tumor growth in cholangiocarcinoma cells, with enhanced inhibition observed upon overexpression of four mitochondrial protein-encoding genes: Succinate Dehydrogenase Complex Assembly Factor 2 (SDHAF2), Mitochondrial Ribosomal Protein S34 (MRPS34), Mitochondrial Ribosomal Protein L11 (MRPL11), and Cytochrome c Oxidase Subunit 8A (COX8A) (67)

In energy metabolism, VIC supports the synthesis of carnitine, which is responsible for transporting fatty acids into mitochondria [7,10]

Ubiquitination also has a possible cross-talk with phosphorylation as it is found that Tau ubiquitination in PHFs is associated with phosphorylation as it precedes ubiquitination and incorporation into PHFs [87,88,89,90]

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