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The newly identified metabolite -Glu-Ser-Gly belongs to the family of -glutamyl tripeptide

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A heat map of differentially expressed genes involved in glutathione metabolism was generated using Heatmap Builder

This is likely to be particularly true for extracellular proteins, or domains, which are cystine-rich and can be exposed to high levels of oxidants, as a result of the low levels of extracellular defense and repair systems, and the long half-life and slow turnover of extracellular matrix proteins and proteoglycans