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The protective effect of flavonoids in the diet on autophagy-related cardiac impairment

Patients with biopsy-confirmed MASH, fibrosis stage 13, and a Non-alcoholic fatty liver disease Activity Score (NAS) 4 were enrolled and randomly assigned for oral daily doses with MSDC-0602K, or placebo, for 12 months

Ferroptosis, first proposed by Dixon et al (5), represents a unique form of cell death, distinct from apoptosis, autophagy and necroptosis, with defining morphological, biochemical and immunological characteristics governed by specific regulatory genes or proteins

It stimulated maximal respiration rates in neonatal rat ventricular myocytes, an effect blocked by specific inhibitors (L-NAME, ODQ, or sGC), indicating its action on mitochondrial pathways (Yamazaki et al., 2014)

Figure 2: Changes in escape latency in the four different experimental groups included in the first part of the study