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For patients who have difficulty absorbing B12 through the digestive tractsuch as those with pernicious anemia, gastrointestinal disorders (like Crohns disease or celiac disease), a history of gastric bypass surgery, or those with severe B12 deficiencyour providers often recommend intramuscular B12 injections

Cochrane Caldern 2007 meta-analysis of 51 RCTs documented symptom SMD 0.73 and medication SMD 0.57 vs placebo among the largest effect sizes in allergy medicine

Variants like C677T and A1298C can reduce enzyme efficiency, potentially leading to higher homocysteine levels and impacting processes like detoxification, neurotransmitter production, and cardiovascular health

They play a role in many natural biological processes by helping cells communicate with one another

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