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Description

In contrast, no significant difference in the expression of all other analyzed ABC transporters was found between these patient groups (Supplementary Fig

Only under the assumption of the high IC 50 of 200 mM (61.85 mg/mL) the lack of CYP3A4 inhibition could be a problem of drug concentration, but this is probably not of clinical relevance, since 400 mg per day is already a relatively high dose