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Disclosures: Rebecca Farr: Nothing to Disclose, Lin Fei: Nothing to Disclose, Rashmi Sahay: Nothing to Disclose, Heidi Kalkwarf: Nothing to Disclose, Kevin Hommel: Nothing to Disclose, Cyd Castro-Rojas: Nothing to Disclose, Mosab Alquraish: Nothing to Disclose, Amy Taylor: Nothing to Disclose, Alexander Miethke: Mirum Pharmaceutical Inc: Grant/Research Support, Mirum Pharmaceutical Inc: Consultant, Ipsen: Speaking and Teaching 710 MULTIPLEXED SINGLE-CELL ANALYSIS REVEALS DISTINCT TUMOR-IMMUNE MICROENVIRONMENT LINKED TO PREMETASTATIC NICHE FORMATION IN STEATOTIC LIVER Jieun Kim 1 So Yeon Kim 1 Jina Kim 1 Alexander Xu 1 Sungyong You 1 Ekihiro Seki 1 , 1 Cedars-Sinai Medical Center Background: Liver metastasis is a critical determinant of prognosis in patients with colorectal cancer (CRC)

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