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Neuroinflammation and the immune system Microglia mediate the immunomodulatory processes in the brain and play a crucial role in the neuroinflammation in PD, leading to chronic activation and releasing of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-) and interleukin-1 beta (IL-1), which further increase the damage in neurons and promote disease progression 41

[7] One example of an epigenetic change in eukaryotic biology is the process of cellular differentiation

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In comparison to healthy control, patients suffering with IBD show a reduced abundance of Firmicutes and a greater prevalence of Enterobacteriaceae (94)

For example, the designation H3K4me3 stands for a trimethylation of the lysine at position 4 of histone 3