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We previously found that acK307 reduces the formation of low activity tetramers and cross-linked inactive dimers (Wright et al., 2018)

465 BrenuEWvan DrielMLStainesDRAshtonKJRamosSBKeaneJet al

To gain insight into the role of cysteine in cellular physiology, characterization of cysteine-regulated cellular signaling is warranted

One new hypothesis is that mitochondrial ROS generated during hypoxia promote the oxidation of cysteine residues within PHD2 resulting in oxidative PHD2 homodimerization and inactivation, leading to HIF- protein stabilization 26