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For the purpose of this work, only glutathione, a small antioxidant peptide was utilized

doi: 10.1016/j.ab.2008.11.046

Consistent with the role of p53 in the enhancement of the PPP, the silencing of p53 also significantly increased both NADP+/NADPH ratio (Figure 5F) and ROS (Figure 2G), similar to the silencing of G6PD (Figure 4I,J)