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(85.5% of patients with CF), and the most common mutation is F508del

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Healthcare providers categorize saddle nose deformities into three stages: minimal saddle nose involves a small depression in the dorsum, moderate saddle nose shows a larger depression with the nose appearing flattened from all angles and the tip potentially turning upward, and major saddle nose displays an obvious lack of bony support and cartilage with the dorsum sinking in and the tip turning upward

doi: 10.1002/hep.31328 119 LiJYFengYHLiYXHePYZhouQYTianYPet al