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As it was recently suggested, GSH depletion could be the Trojan horse of COVID-19 severity and mortality and elevating GSH levels in tissues may decrease COVID-19 severity and mortality rates (Khanfar and Al Qaroot, 2020)

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A similar scenario has in fact been reported recently in an alcoholic liver disease model in which long-term alcohol consumption activated NF-B in Kupffer cells, whereas NF-B activation in hepatocytes was inhibited 45

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