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Given that ATMi reduces the ability to upregulate aerobic respiration, we considered the possibility that this may be the result of altered TCA cycle and electron transport chain (ETC) use

In addition to AD and PD/LBD, GRN variation has also been implicated in Gaucher disease [57], FTLD-TDP and/or motor neuron disease with C9orf72 repeat expansions [58], ALS [59], and limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) [60]

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Citratpuffer sind geeignet, im pH-Bereich von 7 - 7,5 in Konzentrationen von 5 - 40 mMol/l zu stabilisieren.Citrate buffers are suitable to stabilize in the pH range of 7 - 7.5 in concentrations of 5 - 40 mmol / l