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One hallmark example is capecitabine-induced diarrhea , which results from its conversion to 5-fluorouracil (5-FU) in the gastrointestinal mucosa via thymidine phosphorylasean enzyme that is upregulated in tumor and normal epithelial tissues

Betibeglogene autotemcel gene therapy in patients with transfusion-dependent, severe genotype -thalassaemia (HGB-212): a non-randomised, multicentre, single-arm, open-label, single-dose, phase 3 trial