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The thiazolidinedione (TZD) antidiabetic medications for the treatment of type 2 diabetes function as ligands for the gamma subtype of PPARs

The mitochondrial SERAT2;2 is responsible of 80% of SERAT activity (Watanabe et al., 2008)

Due to the multiple and crucial biological roles of Prdx6, alterations in Prdx6 expression and/or function have been implicated in several pathophysiological processes and diseases, including inflammation, cancer, infectious and neurodegenerative diseases, among others [18, 26, 27]

This reaction occurs at (-OH, NH 2 ) hydrophilic site that is already introduced or unmarked during phase I reactions

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