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In one study, short-term IV Vitamin C improved serum levels in alcoholics with depleted vitamin C, but it didnt last and other studies showed 3 months of supplementation was needed to maintain normal blood levels

doi: 10.1093/toxsci/kfm280 243 SchnCBielMMichalakisS

The current studies show that even small increases in ELF GSH observed in the hypertonic exposed CFTR KO mice can still have protective effects against HOCl mediated toxicity, although not nearly to the same degree as occurs in the WT ELF

The risk of bias was variable in the AD blood GSH literature but consistently low in MCI blood GSH literature (Table 3)