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Published April 4, 2012

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Dehydration Causes: Not drinking enough water Excessive sweating, such as during intense physical activity or hot weather Vomiting and diarrhea Fever Certain medications Diabetes Alcohol consumption Infections Kidney problems Aging (older adults are more prone to dehydration) Signs of Dehydration Intense thirst Disorientation or confusion Feeling lightheaded or dizzy Extreme tiredness or fatigue Urine that is darker in color Reduced frequency of urination or diminished urge to urinate Sunken-looking eyes Skin lacking elasticity Faster heartbeat and breathing Decreased blood pressure Mental confusion or delirium What are IV Fluids

Risk of fluid overload Potassium imbalance 2

Standard AOD-9604 Dosing Protocol Subcutaneous Injection Dosing: Beginner: 250 mcg per dose, once daily Intermediate: 300-400 mcg per dose, once daily or divided into two doses Advanced: 500 mcg per dose, once daily or 250 mcg twice daily Oral Administration Dosing (if using oral formulation): Standard: 1-2 mg per dose, once daily on empty stomach Higher protocols: Up to 5-10 mg daily, as studied in clinical trials Frequency: Once daily (morning preferred) or twice daily (morning and early afternoon) Timing: Best administered on an empty stomach, typically upon waking or before exercise Cycle Length: 12-16 weeks for initial assessment, with potential for longer protocols based on response Off Cycle: 4-8 weeks between cycles, though not strictly required based on current research Note: Start at the lower end of the dosing range to assess individual tolerance