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doi: 10.3389/fimmu.2022.784046 16 BenzieIFStrainJJ

Role of oxidative stress in male infertility: an updated review

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These chemical scaffolds frequently yield screening hits due to nonspecific interfering mechanisms such as redox cycling that can generate reactive oxygen species or covalent adducts and metal chelation that can disrupt metalloenzyme function, leading to false-positive results across diverse assay formats (Xie et al., 2011)