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Cellular experiments further confirmed that the L-OPA1/S-OPA1 ratio and Irisin/FNDC5 expression were significantly upregulated in 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR)-treated cardiomyocytes, which significantly increased PINK1/Parkin, SOD2 expression, and LC3II/I ratio, decreased p62 expression, and increased mitophagy and antioxidant capacity in AICAR-treated cardiomyocytes (Yeo et al., 2022)

[DOI] [PubMed] [Google Scholar] 80.Laskin WB, Weiss SW, Bratthauer GL

Think of it as a custom medicinal playlist in which every track is an unregulated injectable, and hitting shuffle could give you sepsis

Modulation of gut microbiota and restoration of metabolic pathways may provide novel therapeutic strategies against MPs-induced skin injury

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