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Valentin N, Neilsen OV, Olesen KH

Patients with this disease may exhibit various abnormalities on cranial magnetic resonance imaging (MRI), including cerebral atrophy, white matter abnormalities, hypoplasia of the corpus callosum, bilateral basal ganglia abnormalities, and symmetric necrosis of the bilateral pallidum

Ferroptosis inducers have the potential to be effective radiosensitizers for radiotherapy (230248) ( Figure 4 )

[DOI] [PMC free article] [PubMed] [Google Scholar] 33

Ultimately, it seems as though injury to the NMJ is a culmination of mutant protein aggregation at the presynaptic nerve terminal, presynaptic cholinergic dysfunction, impaired axonal transport, reduced synaptic acetylcholinesterase, and diseased muscle itself, among others [292]