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Ethical consideration All experimental procedures were approved by the Ethics Committee of Rafsanjan University of Medical Sciences (ID: IR.RUMS.REC.1401.235) and followed national animal care guidelines

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Single-cell karyotyping in colorectal cancer carcinoids confirmed the presence of distinct subclones immediately prior to treatment rather than drug induction, enabling prediction of radiotherapy resistance and guiding personalized herbal combination strategies

In tumor cells, the apoptosis pathway is often impeded by various mechanisms, many of which contribute to intrinsic resistance to chemotherapy, the most prevalent anticancer therapy (104)