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Description

GSR is an anti-oxidative/anti-inflammatory enzyme that reduces glutathione disulfide (GS-SG) to glutathione (GSH) in a NADPH-dependent manner

The latter were grouped into following gene sets to facilitate interpretation: ferroptosis defenses (including GPX4 , FSP1 and GCH1 ), GSH (production of glutathione employed by GPX4), PUFA (increased incorporation of PUFA into membranes promoting ferroptosis), and Iron (increased ferrous iron to catalyze ferroptosis) (Table S2)