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The autophagic degradation of BMAL1/ARNTL mediated by the cargo receptor SQSTM1/p62 (sequestosome1) is reported to promote lipid peroxidation and ferroptosis [106, 374]

These results highlight the validity of these markers as predictors of ARF treatment progress

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On a previous paper using an inflammatory model we used 600 mg/kg and 300 mg/kg and demonstrated that doses of 300 mg/kg were adequate for neuroprotection 17

FIGURE 3 The post-exercise blood lactate levels detected in rat models subjected to exhaustive swimming or treadmill tests showed that acute or short-term peptide supplementation (e.g., at dosages of 200600 mg/kg/day) was able to greatly reduce lactate accumulation when measured immediately post-exercise (61), interfering with reducing the oxidative injury of muscle tissue during maximal exercise