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KPV enters cells via a transporter that is upregulated in inflamed tissues, providing targeted delivery to areas of active inflammation

For this reason supplementing with a quality protein like PRO-30G is a great first step

10.1053/jhep.2002.34943 Hepatology 202 ZhongQ.PuttD

The inability of DAF-16 to induce its targets in LRO mutants together with its nuclear retention strongly suggests that LRO-dependent signals are indispensable for DAF-16 transactivation in response to BA stress