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Given the lack of rare missense variants that have been annotated as likely benign or benign in ClinVar, we instead used gnomAD variants (after excluding known or suspected pathogenic variants) as a negative reference set

The foremost important reaction of O 2 is dismutation, non-enzymatic, or by SOD, where it reacts with another molecule of O 2 resulting in oxidation of its one molecule to oxygen and reduction of the second to H 2 O 2

Yusuf, M., Khan, M., Khan, R