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The enzymes responsible for GSH synthesis, such as glutamate-cysteine ligase modifier subunit (GCLM) and the glutamate-cysteine catalytic subunit (GCLC), and enzymes related to GSH utilization, such as glutathione reductase, glutathione peroxidase and glutathione S transferase (GST), have their transcription regulated by the transcription factor NRF2 (nuclear factor, erythroid-derived 2-like 2 factor), known as the master regulator of antioxidant response 16

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Exaggerated activation of nuclear factor-B and altered IB- processing in cystic fibrosis bronchial epithelial cells