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These immune responses, including the release of pro-inflammatory cytokines (e.g., TNF-, IL-1), can signal to the brain via the vagus nerve and the systemic circulation (Ma et al., 2020)

Modulation by pregnenolone sulfate of filtering properties in the hippocampal trisynaptic circuit

For instance, research shows MOTS-c drives glucose into the pentose phosphate pathway (for anabolic needs and antioxidant defense) rather than burning it immediately via glycolysis, while simultaneously increasing fatty-acid oxidation by upregulating carnitine shuttle activity in mitochondria

& Gong, D

Geerling BJ, Badart-Smook A, Stockbrgger RW, Brummer RJ