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PMID 4737475

PMCID: PMC3580441

Such channel modifications alter ion flow, transmembrane potential, and reduce both APD and conduction velocity, ultimately disrupting cardiac electrophysiological activity and elevating the risk of arrhythmias (Karam et al., 2017)

Higher concentrations (10mg/ml) reduce the number of doses per vial and require more frequent reconstitution, increasing peptide waste and protocol complexity