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Reversible epigenetic fingerprint-mediated glutathione-S-transferase P1 gene silencing in human leukemia cell lines

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Findings from clinical studies also revealed high expression of circulating microRNAs (miRNAs) in the colonic tissues of IBS patients, suggesting the involvement of epigenetic and genetic events in modulating intestinal signaling pathways, particularly serotonin receptor gene with a cis -regulatory variant on the somatic hypersensitivity and intestinal permeability of IBS patients (Kapeller et al., 2008)