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For instance, Nf2-deletion, hepatic inactivation of HPO1/2 lead to generation of HCCs, iCCAs (intrahepatic cholangiocarcinomas), and mixed hepatocellular cholangiocarcinomas

Oxidative stress, resulting from an imbalance between free radical production and the bodys antioxidant defenses, is a major contributor to aging and the development of various diseases (53)