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Epirubicin (EPI) is widely used for the therapy of TNBC but its limited in clinical use due to cardiotoxicity and chemotherapy resistance

ACS Nano 6 (5), 40014012

While KYN itself is not neuroactive, it is a branching point for two major metabolic routes: one leading to the synthesis of kynurenic acid (KYNA), which occurs in astrocytes, and another leading to the synthesis of picolinic acid (PA) and quinolinic acid (QA), occurring in microglia, with QA serving as a precursor for nicotinamide adenine dinucleotide (NAD) [25, 26]

Clemmensen C, Chabenne J, Finan B, Sullivan L, Fischer K, Kuchler D, et al

Just Ingredients - The Inflammatory Reset: Your Guide to Reducing Inflammation | Understand and manage chronic inflammation |30-Day Meal Prep Food Cookbook for Gut Health and Anti-Inflammatory Diet | [Dr