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These bonds will be cleaved within the acidic environment in endosomes and lysosomes, which will expose the positively charged amino groups of the polymer backbone and trigger the influx of H + and Cl , resulting in the elevation of endosomal osmotic pressure and the inflow of H 2 O

447 Inhibiting sEH activity provided significant protection against islet cell damage and improved glucose homeostasis in streptozotocin-induced diabetes

Unraveling these pleiotropic roles may uncover previously unrecognized regulatory networks and identify targetable vulnerabilities for precision oncology interventions

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It interacts with the nitric oxide pathway, providing benefits like improved oxygen transport