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Kang TH, Friedmann T

Nat Med 2013;19:114752

Figure 3Da depicts the pseudotime trajectory of progenitor cells, with branches corresponding to differentiated cell types integral to cartilage and epithelial regeneration

On microglial cells, the mechanism of AMPK activation through ROS and calcium signaling pathways during P2X7R stimulation, leading to mitochondrial division, induction of mitophagy, and activation of the nuclear transcription factor TFEB has been proven (Sekar et al., 2018)

GPX converts peroxides and hydroxyl radicals to non-toxic forms by oxidizing GSH to glutathione disulfide, which is then reduced to GSH by glutathione reductase ( The antioxidant response is modulated mainly by the Nrf2/Keap1 system (Figure 2)