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Barbui C, Cipriani A, Patel V et al

In addition to immune dyshomeostasis, environmental factors, such as lifestyle and diet, have been implicated in the pathogenesis of such diseases (12)

The logic is that sustained exposure over a longer window may matter more than peak concentration particularly for an epigenetic mechanism that operates through gene expression changes, which take time to manifest

Under such circumstances, oxidative stress is thought to largely regulate the muscle conditions after exercise 11,12,13 and it is thus important to balance the oxidative state with that of the antioxidant defence capabilities