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During biotransformation in the gut, proanthocyanidins rely on the hydrophilic paracellular pathway, or endocytosis, to enter the systemic circulation due to the lack of proanthocyanidin receptors in cell membranes

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In parallel, gut-resident T cells conditioned by the microbiota (for instance, pro-inflammatory Th17 cells versus anti-inflammatory regulatory T cells) can traffic to the CNS [38]