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Per the applicant, the Total Ankle Talar Replacement is a patient specific, metallic spacer that is a solid, polished replica of a patient's physiologic talus and intended to articulate to the surrounding native bone anatomy (that is, calcaneus and navicular)

Food and Drug Administration (FDA) has granted Breakthrough Therapy Designation status to Rituxan (rituximab) for pemphigus vulgaris, a rare, serious and life-threatening condition characterized by progressive painful blistering of the skin and mucous membranes

This metabolic reprogramming is associated with exacerbated oxidative stress, neuroinflammation, and accelerated pathological progression

In addition, the generation of ROS by platelets, the absorption of free radicals from the environment, and the depletion of antioxidants can lead to pro-oxidant, pro-inflammatory, and platelet hyperaggregability effects, which increase the risk of CVD (178)

Uptake of GdVO 4 :Eu 3+ NPs triggers Ca 2+ -mediated eryptosis [459]