glutathione cysteine conjugate Metabolism of GSH conjugated product to mercapturic acid conjugated Detection and Characterization of a

found that Cu drives protein lipoylation and aggregation, resulting in proteotoxic stress and further inducing cell death [5]

However, further research on this topic is needed

And what I think we have to do is try and educate them better

for such mechanism full activation (opening) of SV/TPC1 channels, which is only observed at rather high cytosolic Ca 2+ , is not necessary so that the channel protein may operate in a non-canonical ion flux-independent way (Pottosin & Dobrovinskaya, Reference Pottosin and Dobrovinskaya2022)

PMID: 36725884 Mol Psychiatry MEK1/2 inhibition rescues neurodegeneration by TFEB-mediated activation of autophagic lysosomal function in a model of Alzheimer's Disease