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doi: 10.3389/fphys.2025.1584195 Received 27 February 2025 Accepted 21 May 2025 Published 01 July 2025 Volume 16 - 2025 Edited by Walter Swardfager, University of Toronto, Canada Reviewed by Andrea Deledda, Azienda Ospedaliero-Universitaria Cagliari, Italy Natasha Anita, University of California, San Diego, United States Updates Copyright 2025 Hinman, Alan and Lee

SAG has also restored GSH levels in cells depleted by HSV-1 infection and shown antiviral activity in murine retroviral models, outperforming GSH in direct comparisons

Butyrate-producing bacteria having anti-inflammatory properties such as Clostridium , Roseburia , and Faecalibacterium species, have reduced significantly in T2D patients, while the population of gram-negative bacteria, such as Escherichia, increases high levels of lipopolysaccharides, LPS

Excessive fat accumulation inflames adipose tissue during obesity and favors adipose tissue macrophages (ATM) polarization from an anti-inflammatory to a pro-inflammatory phenotype, leading to further recruitment and infiltration of macrophages and other immune cells