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Studies show that short- and long-term supplementation is safe and well tolerated in healthy individuals and in a number of patient populations, a paper released via Current Sports Medicine Reports asserted

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On three visits (before, 3 months in, and after 6 months of supplementation), subjects exercised for 30 min on a low intensity (50% Wmax), 30 min on a higher intensity (80% Wmax), and finally performed a 30 min all-out time trial test