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The targeted delivery of dexamethasone to GLP1R-positive cells prevented typical dexamethasone offtarget effects on glucose metabolism, bone density, and the hypothalamus-pituitary-adrenal axis activity (164)

Trigeminal Neuralgia, sometimes called Tic Douloureux, is a serious nerve condition that causes sudden, severe facial pain, usually on one side of the face

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Generally well tolerated

This dual preservation creates a unique metabolic environment where cells can simultaneously maintain high energy production capacity and robust epigenetic regulation a combination that typically requires careful balance between competing metabolic demands