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A recent study reported that oral large dose deucravacitinib (30 mg/kg QD) showed the similar equivalent efficacy to ustekinumab rather than medium dose deucravacitinib (10 mg/kg QD) in IL-23-driven psoriasis-like model ( K17 activates the transcription factor STAT3 under induction of deleterious ROS production in keratinocytes along with Cyclin D1, leading to the hyperproliferation of keratinocytes ( TNF-, IL-6, IL-17 and IL-22 ( Our study also has some limitations

Int J Mol Sci (2021) 22(17):9459

Moreover, ROS can inhibit protein phosphatase PP2A by oxidizing cysteine residues at its active site, thereby reducing its catalytic activity (78)

There is also no published stability data for the two held in a single solution