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Chandys hypothesis, that the rapid onset of the repairing processes induced by B12 shots might overwhelm the system and temporarily cause a worsening in symptoms, similar to the Jarisch-Herxheimer reaction in those treated for Lyme disease

Typically, B12 injections are administered once a week

It isn't approved as a standalone weight management treatment, but weight loss is a recognised secondary effect of GLP-1 receptor agonists, and it's sometimes prescribed alongside diabetes management where weight loss is also a goal