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In a randomized study involving 37 patients with burns covering over 30% of their total body surface area, it was found that administering high-dose ascorbic acid as an adjuvant within the first 24 hours after thermal injury significantly reduced the need for resuscitation fluids, improved body weight gain, wound edema, and severity of respiratory dysfunction, and decreased serum malondialdehyde (MDA) levels (Tanaka et al., 2000)

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Exp Cell Res 204 : 5460 Gambarana C, Ghiglieri O, Taddei I, Tagliamonte A, De Montis MG