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73 HIF-1 promotes IL-1 production and drives inflammation by shifting activated macrophage metabolism from oxidative phosphorylation to glycolysis, with the resulting lactate serving as a key mediator of macrophage phenotype through epigenetic and chromatin-mediated gene regulation

Since GSH was not detected in cell walls or intercellular spaces, the loading is suggested to take place through plasmodesmata [159]

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The scoring of immunohistochemical stains in each specimen was determined using a histological score (H) 48