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Author: Janet Piero Why Target Selection Matters Target selection remains a key determinant of success in pharmaceutical R&D, as efficacy and safety issues continue to drive late-stage failures

Scheme 1 illustrates the reduction in the Cu(II)-neocuproine complex to the Cu(I)-neocuproine complex, which is measured via spectrophotometry at a wavelength of 450 nm (CUPRAC method)

Pairing increased L-dopa administration with dietary L-tryptophan is a competitive inhibition mismatch which converts L-dopa from a nutrient to a drug with its accompanying side effects

Dalton Trans 31073120 Strausak D, Solioz M (1997) CopY is a copper-inducible repressor of the Enterococcus hirae copper ATPases

J Thromb Haemost (2009) 7(10):170310