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December 24, 2025

in contrast, VPS35 mutations are rare in Asian populations, except for Japanese populations ( VPS35 indicates that retromer complex dysfunction is a component of PD, our understanding of the molecular and cellular mechanisms of neurodegeneration is still limited

4 1 C metabolism and anti-tumor therapy As discussed earlier, enzymes and metabolites involved in the synthesis and utilization of 1 C units are critical drivers of tumorigenesis and progression, either through their canonical enzymatic activities or through non-canonical functions