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Notably, transient rises in pyroglutamic acid have been reported with certain common medications and with states of high oxidative demand, which underscores that a single elevated reading usually reflects a temporary imbalance in the loop rather than a fixed genetic problem

2017;26(3):177-81 Weschawalit S, Thongthip S, Phutrakool P, Asawanonda P

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G6PD deficiency typically manifests as haemolytic anaemia due to red cell oxidative damage but, in severe cases, also results in infections due to lack of leucocyte oxidative burst, highlighting the dual redox roles of the pathway in free radical production and detoxification

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